OXB–302

OXB–302

Cancer (Multiple)
Pre–Clinical complete

OXB-302

Gene-based immunotherapy targeting a range of cancers

Status: Pre–Clinical complete

Immunotherapy

OXB-302 is a gene-based cancer immunotherapy targeting a wide range of tumours and a number of haematological malignancies.

Our approach

OXB-302 is a novel oncology product that combines Oxford BioMedica’s lentiviral vector platform and 5T4 technology platforms.  This cell therapy uses the LentiVector® platform to engineer patients’ harvested T-cells to express an antibody against the 5T4 antigen, which is expressed on the cell surface in many common cancers.  These T-cells are then infused back into the patient, and subsequently recognise the 5T4 tumour antigen and initiate cell killing immune mechanisms.

Proof of concept

OXB-302 has completed pre-clinical development, delivering encouraging efficacy in an industry standard in vivo tumour challenge model. 

Clinical status

Following the successful completion of preclinical development, planning for a Phase I/II clinical study is well underway, with a regulatory submission anticipated in the near future. 

Market opportunity

The targeted cancer treatment and immunotherapy market is forecast to grow to $36.8 billion by 2019. With a large number of cancers expressing the 5T4 antigen, OXB-302 has significant market potential if successful in any of its target indications.