Press releases

Oxford BioMedica Announces Exercise of Option by ImaginAb

-- ImaginAb acquires exclusive worldwide licence for 5T4-based imaging diagnostic --

Oxford, UK and Los Angeles, CA – 29 November 2012: Oxford BioMedica (“Oxford BioMedica” or “the Company”) (LSE: OXB), the leading gene-based biopharmaceutical company, today announces that ImaginAb, Inc. (“ImaginAb”), a biotechnology company specialising in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications, has exercised its option to acquire an exclusive worldwide licence for commercialisation of an in vivo 5T4-based imaging diagnostic. 

Following the initiation of the companies’ research collaboration in 2011, ImaginAb has successfully re-engineered Oxford BioMedica’s anti-5T4 antibody into a smaller protein format with kinetics suitable for in vivo diagnostic imaging of tumours expressing the 5T4 antigen.  5T4 represents an important target for therapeutics and diagnostics in oncology given its restricted expression in normal tissues and its high prevalence on both primary and metastatic tumours.  ImaginAb is preparing to initiate clinical development of the 5T4 in vivo diagnostic in 2013.

John Dawson, Chief Executive Officer of Oxford BioMedica, said: “Targeted molecular imaging for the diagnosis and staging of cancer holds significant promise in the era of personalised medicine, and we are pleased that our anti-5T4 technology has demonstrated such clear potential for cancer diagnostic imaging.”

Dr Christian Behrenbruch, Chief Executive Officer of ImaginAb, said: “5T4 is an important target in oncology that has considerable diagnostic and therapeutic potential. Our highly productive collaboration with Oxford BioMedica has yielded a very promising imaging agent that is a significant addition to ImaginAb’s best-in-class oncology diagnostic portfolio.”

Under the terms of the agreement, Oxford BioMedica will receive an upfront option exercise payment and could receive proceeds up to a total of US$4 million in initiation and development milestone payments, in addition to royalties on product sales, subject to the achievement of certain programme objectives.


Notes to editors

About Oxford BioMedica

Oxford BioMedica (LSE:OXB) is a leading gene and cell therapy group focused on developing life changing treatments for serious diseases. Oxford BioMedica and its subsidiaries (the "Group") have built a sector leading lentiviral vector delivery platform (LentiVector®), which the Group leverages to develop in vivo and ex vivo products both in-house and with partners. The Group has created a valuable proprietary portfolio of gene and cell therapy product candidates in the areas of oncology, ophthalmology and CNS disorders. The Group has also entered into a number of partnerships, including with Novartis, Bioverativ, Sanofi, Axovant, Orchard Therapeutics, Boehringer Ingelheim/UK Cystic Fibrosis Gene Therapy Consortium/Imperial Innovations, GC LabCell and Immune Design, through which it has long-term economic interests in other potential gene and cell therapy products. Oxford BioMedica is based across several locations in Oxfordshire, UK and employs more than 320 people. Further information is available at

For further information please contact

Oxford BioMedica plc

John Dawson, Chief Executive Officer
Stuart Paynter, Chief Financial Officer
Sarah MacLeod, Head of Communications
Tel: +44 (0)1865 783 000

Financial and corporate communications enquiries:
Consilium Strategic Communications
Mary-Jane Elliott/Matthew Neal/Olivia Manser/Laura Thornton
Tel: +44 (0)20 3709 5700