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2004/OB/12
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OXFORD
BIOMEDICA PUBLICATION – LENTIVECTOR®
GENE DELIVERY SYSTEM RESULTS IN HIGH SUCCESS RATE IN AVIAN
TRANSGENICS PROGRAM
Collaboration
with Viragen Inc. and Roslin Institute
Oxford
BioMedica (LSE OXB), the leading gene therapy company, today
announced that a scientific article reporting on its collaboration
with Viragen Inc (AMEX: VRA) in the field of Avian Transgenic
Biomanufacturing is available as an advance online publication
of EMBO reports (European Molecular Biology Association,
McGrew et al, VOL 5, NO 7). The article, titled “Efficient
production of germline transgenic chickens using lentiviral
vectors”, reports data that demonstrate that Oxford
BioMedica’s lentiviral vectors can be used to generate
transgenic lines with an efficiency of the order of 10 to
100-fold higher than any previously published method.
In collaboration
with Roslin Institute and Oxford Biomedica PLC, Viragen aims
to develop this technology for the efficient, large-scale
and cost-effective manufacturing of pharmaceutical protein-based
drugs in the eggs laid by flocks of transgenic chickens.
Project
Leader, Roslin Institute’s Dr. Helen Sang, commented,
“Our results to date are very encouraging. The efficiency
is such that transgenic lines of chickens can be established
with ease, and studies measuring expression of the transgene
suggest that predictable levels of expression will be obtained.
In order to achieve our goal of producing therapeutic proteins
in hens’ eggs, we must accomplish tissue specific expression
of the transgene in the oviduct – a goal we are diligently
working toward.”
Commenting
on the results, Oxford BioMedica’s Chief Executive Officer,
Prof. Alan Kingsman said “This is an interesting
project and we are delighted to see the LentiVectors having
a significant impact in yet another area of commercial biology”.
The abstract
of the article is available here.
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| Notes
| 1. |
Oxford
BioMedica plc |
|
Oxford
BioMedica (LSE: OXB) is a biopharmaceutical
company specialising in the development
of novel gene-based therapeutics with a
focus on the areas of oncology and neurotherapy.
The Company was established in 1995 as a
spin out from Oxford University, and is
listed on the London Stock Exchange.
In
addition to its technical expertise in gene
delivery, Oxford BioMedica has in-house
clinical, regulatory and manufacturing know-how.
The development pipeline includes two novel
anti-cancer products in clinical trials;
and two neurotherapy products in advanced
preclinical development for Parkinson’s
disease and retinopathy. The Company is
underpinned by an extensive preclinical
and research portfolio and about 70 patent
families, which represents one of the broadest
patent estates in the field.
The
Company has a staff of approx. 65 split
between its main facilities in Oxford and
its wholly owned subsidiary, BioMedica Inc,
in San Diego, California. Oxford BioMedica
has corporate collaborations with Wyeth,
Intervet, Merck & Co, Amersham and Kiadis. |
| 2. |
Avian
Transgenic Technology |
| |
Viragen
holds the worldwide exclusive license to
commercialize Avian Transgenic Technology
as granted by Roslin Institute (Scotland).
The project is designed to develop the common
chicken into a pharmaceutical bioreactor,
one that can meet the growing need for protein-based
human therapeutics. Based on the creation
of lines of transgenic hens which have been
engineered to produce the target protein
in their eggs, this technology is being
developed as a cost-effective and efficient
alternative to standard biomanufacturing
techniques, having many apparent advantages
in ease of scale-up, lower costs of production
and quality of product produced. The proportion
of protein drugs, including monoclonal antibodies,
under development is forecast to be expanding
rapidly and manufacturing constraints, including
lack of adequate facilities, have been recognized. |
| 3. |
LentiVector®
Technology |
| |
LentiVector
is a gene delivery vector that is based
on lentiviruses. The system contains only
the few viral components that are required
for efficient gene delivery. Oxford BioMedica
has shown that minimal lentiviral vectors
are able to deliver genes to a wide range
of dividing and non-dividing cells, including
neurones in the brain. Oxford BioMedica
has three issued US patents for its LentiVector
technology, and works with vectors based
on HIV and Equine Infectious Anaemia Virus
(EIAV), a horse virus that is not linked
to any disease in humans. The EIAV system
is Oxford BioMedica’s system of choice
because of its superior safety profile.
The
Company has established a neurotherapy pipeline
of product candidates based on its LentiVector
technology, which includes ProSavin®
for Parkinson’s disease, RetinoStat®
for retinopathy, MoNudin®
for motor neuron disease and Innurex®
for nerve repair. |
| 4. |
Viragen,
Inc. |
| |
Viragen is a biotechnology company specializing in the research,
development and commercialization of natural
and recombinant protein-based drugs designed
to treat a broad range of viral and malignant
diseases. These protein-based drugs include
natural human alpha interferon, monoclonal
antibodies and a peptide drug. Viragen’s
strategy also includes the development of
Avian Transgenic Technology as a biomanufacturing
platform for the large-scale, cost-effective
production of therapeutic proteins.
Viragen is publicly traded
on the American Stock Exchange (VRA). Viragen’s
majority owned subsidiary, Viragen International,
Inc., is publicly traded on the Over-The-Counter
Bulletin Board (VGNI). Viragen’s key
partners and licensors include: Roslin Institute,
Memorial Sloan-Kettering Cancer Center,
Cancer Research UK, University of Nottingham
(U.K.), University of Miami, America’s
Blood Centers and the German Red Cross.
Further
information is available at http://www.Viragen.com |
| |
| For
further information please contact:
|
|
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Oxford BioMedica plc
Professor Alan
Kingsman, Chief Executive
|
Tel: +44 (0)1865 783 000 |
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Court
Buchanan Communications |
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