Oxford BioMedica
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The LentiVector® platform

Why use a lentiviral vector?

Factors that influence the selection of a delivery system for gene therapy include the target cell type, the duration of gene expression required for therapeutic effect, and the size of the genetic payload. The versatility of the LentiVector® platform and its ability to deliver genetic material efficiently and stably makes it a valuable tool for gene therapy and gene knockdown using RNA interference. The platform can be used in many therapeutic areas, but it has specific advantages in neurological and ocular disorders. In addition, as Lentiviral vectors integrate the gene of interest into target cells, they are particularly suited to the efficient genetic modification of dividing cells such as hematopoietic stem cells and T-cells. A single administration of a lentiviral vector-based gene therapy could achieve permanent therapeutic benefit. As a research tool, the technology also has applications in transgenesis, stem cell manipulation, somatic disease models, target validation and gene discovery.



The LentiVector® platform is protected by a comprehensive patent portfolio of more than 100 patents and patent applications