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HYPOXIA
AND DISEASE
Low oxygen concentration, or hypoxia, is a salient feature of several
important diseases. For example, in cancer, the hypoxic environment
of a solid tumour induces expression of angiogenic factors that
stimulate the development of a blood supply to the tumour. In inflammatory
disease, swelling leads to blood vessel occlusion and hypoxia. This
in turn leads to the induction of expression of inflammatory cytokines.
In retinopathy, poor blood supply to the retina results in localised
hypoxia, which induces aberrant blood vessel growth leading to visual
obstruction. In cardiovascular disease and anaemia, low oxygen concentrations
are a direct result of the disease.
TECHNOLOGY
The hypoxia response
element (HRE) is a proprietary gene switch that imposes oxygen mediated
control on any linked gene.
APPLICATIONS
Cancer
Anaemia
Cardiovascular disease
Retinopathy
Inflammation
| COMMERCIALISATION
STRATEGY |
| Oxford
BioMedica is seeking partners in the major aspects of its
hypoxia
programme: |
- Joint
development of products
- Licensing
of HRE for use in the partner’s products
- Customised
hypoxia-regulated gene screens
- Licensing
rights to output from the hypoxia-regulated gene discovery
programme
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Website by College Hill - Life Sciences |
